Description

FELINTRA Oral Solution

Itraconazole Oral Solution for cats

Manufactured by: SAVA VET / SAVA Healthcare Limited

Doses form: Solution

Presentation: 

60 ml

Ingredients & Composition:

Each ml contains:
Itraconazole BP 10mg
Flavoured Base  q.s.

Description / Action: 

FELINTRA oral solution for cats contains itraconazole which has broad spectrum of activity against yeast and fungus. It has enhanced tissue penetration, residual effect and higher safety margin.

It is US FDA approved in dermatophytosis caused by Microsporum canis in cats. Itraconazole has superior antifungal potency & fungicidal activity. Oral solution is more bioavailable and has lesser Gl side effects.

Wood’s lamp examination of hair showing classic apple-green fluorescence of M. canis.

How does Itraconazole work?

Itraconazole is delivered to the target tissues like skin, hair and and sebaceous glands, where it accumulates and remains for a much longer period than the duration of treatment. This enables effective short and safe periods of pulse treatment and diminishes the chance of a relapse.

Mean relative inhibition factors (%) of itraconazole and other antifungals

Antifungal agent                Dermatophytes          Aspergillus spp.

Itraconazole                                 12                                25
Ketoconazole                               18                                55
Griseofulvin                                 58                                97
Nystatin                                          46                                68

1%: optimal antifungal activity; 100%: no antifungal activity

Itraconazole is fungicidal at low concentrations against the following clinically relevant pathogens

Strain                         Fungicidal activity after various contact durations (hours) at the stated concentrations

10 µg/ml            100 µg/ml          1000 µg/ml

M. canis                              6h                              2h                       0.17 h
T. mentagrophytes         6h                              1h                       0.17h
C. albicans                          24h                           3h                       0.25h
A. fumigatus                      24h                          4h                       0.25h

Class: Antifungal   

Indication / Uses:

Indicated in cats for treatment of fungal / yeast infections

•  Histoplasmosis
•  Cryptococcosis
•  Blastomycosis
•  Sporotrichosis
•  Dermatophytosis
•  Dermatophyte granuloma

Dosage and administration:

Recommended dosing of Itraconazole in cats

Histoplasmosis         

10mg/kg daily,
1ml/kg daily

Cryptococcosis         

50-100 mg per cat per day for many months. Mean treatment time is 8.5 months
5-10ml daily

Blastomycosis

10 mg/kg PO once a day or divided twice a day. Continue for 2-3 months or until active disease is not apparent
1ml/kg once or twice daily

Sporotrichosis

5-10 mg/kg once daily for 30 days beyond complete resolution of detectable lesions
0.5-1ml/kg once daily

Dermatophytosis

5 mg/kg PO once daily on an every other week schedule. Treatment is generally continued for three “pulses” of one week on, one week off. Give until culture is negative 2 times at two week intervals

0.5ml/kg once daily as pulse dosing every other week for 3 weeks.

Pulse dosing of FELINTRA in dermatophytosis

Recommended daily dosage 5mg/kg (0.5ml/kg) once daily

Weight (kg)    0.5        1            2       3       4       5       6       7         8       9       10

Dose (ml)       0.25     0.50      1       1.5     2       2.5    3       3.5    4       4.5      5

Week 1 – Treat cat daily for 7 days
Week 2 – Do not treat
Week 3 – Treat cat daily for 7 days
Week 4 – Do not treat
Week 5 – Treat cat daily for 7 days

Dermatophyte granuloma

10 mg/kg PO once daily for weeks to months, at least one month beyond clinical resolution and until brush culture is negative x 2
1ml/kg daily for weeks to months

Administer with food to increase bioavailability.

Overdoses / Side effects / Contraindications /Warnings:

Itraconazole may cause hypokalemia or increases in liver function tests in a small percentage of patients. Use itraconazole in patients with hepatic impairment only when the potential benefits outweigh the risks. Adverse effects appear to be dose related. Gl effects (anorexia, weight loss, vomiting), hepatotoxicity (increased ALT, jaundice) and depression have been noted. With long-term therapy, routine liver function tests are recommended (monthly ALT).

What makes FELINTRA unique?

Itraconazole in FELINTRA is more readily available in target tissues because of the addition of cyclodextrin or cyclic carbohydrate in the formulation.

1. Cyclodextrin is hydrophilic outside and is hydrophobic inside
2. A complex is formed by trapping Itraconazole inside the core of Cyclodextrin molecule.
3. Itraconazolemolecule is highly lipophilic and Keratophilic + Cyclodextrin is added to improve water solubility & bioavailability of Itraconazole
4. Itraconazole has very poor water solubility. The formation of complex with cyclodextrin helps in increased dissolution and bioavailability of Itraconazole.

Pharmaceutical precautions / Instructions: 

Store in a cool and dry place at room temperature below 25°C. Protect from light. Keep reach out of the children and dogs. Strictly for veterinary use. Not for human use. For treatment of cats only.

Safety: Age / Pregnancy/ Withdrawal:

Should not be used in pregnant animals.

Substitute: Vetconazole Syrup, Itrapet Capsules Tablets and Oral Suspension, Izof Oral Solution, SUBA vet-IT 50 Capsules, Itron Tablet and Oral Suspension,

Also see terboPET Tablets (Terbinafine),