Description

Cephavet Dry Syrup

Brand Name: Cephavet Dry Syrup

Manufactured by: SAVA VET / SAVA Healthcare Limited

Doses form: Tablets

Presentation: 

60 ml with measuring/dosing syringe

Ingredients & Composition:

Each 5 ml of reconstituted Cephavet  suspension contains
Cephalexin / Cefalexin Sodium IP eq. to anhydrous Cephalexin         250 mg
Excipients:                q.s.
Colour:                       Erythrosine

Description / Action: 

Cephalexin/Cefalexin is an antibiotic of the first-generation cephalosporin group. Cephalexin/Cefalexin has both gram-negative and gram-positive activities. It binds to proteins involved in bacterial cell wall synthesis.

Cephalexin has greater activity against Staphylococci and gram-negative bacteria. It has excellent activity against Staphylococcus spp, Streptococcus spp, E. coli, Proteus, and Klebsiella.

Cephalexin belongs to the cephalosporin family of bactericidal antibiotics. Like other ß-lactam antimicrobials, cephalexin exerts its inhibitory effect by interfering with bacterial cell wall synthesis. This interference is primarily due to its covalent binding to the penicillin-binding proteins (PBPs) (i.e., transpeptidase and carboxypeptidase), which are essential for the synthesis of the bacterial wall.

Cephalexin is readily and almost completely absorbed following oral administration (90% absolute bioavailability). Blood concentrations are proportional to dose within the range of at least 15 to 45 mg/kg. Binding to canine plasma proteins is low, ranging from 9 to 13% cephalexin concentrations of 0.5 to 100 µg/mL.

Food reduces the peak cephalexin concentrations but has negligible effect on the extent of absorption.

Class: Antibiotic / Cephalosporin (1^st Generation)

Indication / Uses:

Cephalexin / Cefalexin / Cephavet is indicated in dogs and cats for

• Primary or secondary bacterial Skin infections
• Urinary tract infections
• Respiratory tract infections
• Bone and joint infections

Dosage and administration:

Cephalexin / Cefalexin / Cephavet can be in given

Dogs @30 mg/kg  or 3 ml/5 kg bodyweight every 24 hours or once daily

Cats @20 mg/kg or 1 ml/2.5 kg bodyweight every 24 hours or once daily

(For Dogs, recommended dose is 15 mg/kg of body weight twice or 30 mg/kg of body weight once a day. For cats, recommended dose is 20 mg/kg once a day. Appropriate culture and susceptibility tests should be performed before treatment to determine the causative organism and its susceptibility to cephalexin. Antimicrobial therapy should be adjusted according to the tests. If acceptable response to treatment is not observed, then the diagnosis should be re-evaluated and appropriate alternative therapy considered.)

Route: Oral – can be mixed with the food

Species: Dogs and cats

Directions for reconstitution: Slowly add boiled and cooled water up to the mark on the bottle. Shake vigorously and adjust the volume up to the mark by adding more water if necessary. This makes 60 ml of suspension. Reconstituted suspension can be used within 7 days after reconstitution,

Overdoses / Side effects / Contraindications /Warnings:

Overdose can be monitored and treated symptomatically.

Dogs/ cats hypersensitive to cephalosporins may show an adverse reaction on administration. Do not use in pets having a known history of allergic reaction towards Cephalexin / Cefalexin.

Vomiting and diarrhoea are the most common side effects, can be administered with food to reduce such reactions. In the event of an allergic reaction such as shortness of breath, rash, hives, vomiting, diarrhea, mucous or blood in the stool, swelling of the lips, tongue, or face, and unusual bleeding or bruising.

Do not give or use along with amphotericin, loop diuretics like furosemide, bacteriostatic antibiotics like erythromycin, tetracyclines.

Pharmaceutical precautions / Instructions: 

Store in a cool and dry place at room temperature or below 25°C. Protect from light. Strictly for veterinary use.

Antimicrobials, including penicillins and cephalosporins, can cause allergic reactions in sensitized individuals. Sensitized individuals handling such antimicrobials, including cephalexin, should avoid contact of the product with the skin and mucous membranes in order to minimize the risk of allergic reactions.

Safety: Age / Pregnancy/ Withdrawal:

Do not use in case of known hypersensitivity to Cephalexin / Cefalexin. The safe use of CEPHAVET oral suspension in dogs and cats intended for breeding and use in pregnancy or lactation not been evaluated. Always follow the recommended dose. It has no reported withdrawal side effects.

Habit forming:  No

Substitute: Lixen Tablets, PalaCef – Vet 300 mg / 600 mg Palatable Tablets, Kephelexin Vet Tablet,  Cephavet 300, 600 mg Tablets, Vetalexin Tablets & Dry Syrup, Phexil Tablets,