Pawsef 375 750 mg Ceftriaxone Sulbactam Injection
Pawsef injection comes with third generation cephalosporin ceftriaxone and betalactamase inhibitor sulbactam. Inhibition of mucopeptide synthesis in the bacterial cell wall is the reason of bactericidal action of ceftriaxone. In the presence of beta-lactamases like penicillinases & cephalosporinases, it has a high degree of stability.
Description
Pawsef 375 / 750 mg Injection
Ceftriaxone Tazobactum Injection
Manufactured by: Neo Kumfurt PH / Kaizen
Dosage form: Dry powder for injection
Presentation:
Pawsef 375 mg & 750 mg vials
Along with 5 ml of sterile water for injection
Ingredients & Composition:
Pawsef 375 mg Injection contains
Ceftriaxone Sodium 250 mg
Sulbactam 125 mg
Pawsef 750 mg Injection contains
Ceftriaxone Sodium 500 mg
Sulbactam 250 mg
Description / Action:
Pawsef injection comes with third generation cephalosporin ceftriaxone and betalactamase inhibitor sulbactam. Inhibition of mucopeptide synthesis in the bacterial cell wall is the reason of bactericidal action of ceftriaxone. In the presence of beta-lactamases like penicillinases & cephalosporinases, it has a high degree of stability.
Ceftriaxone is effective against both Gram -ve & Gram +ive bacteria. Gram positive susceptibility includes certain staphylococcal & streptococcal organisms. Gram negative susceptibility includes Enterobacter spp., Bacteroides spp., Klebsiella spp., E. coli, Pseudomonas aerogenosa, Proteus spp., & serratia spp.
Ceftriaxone is widely distributed across organ systems and is well absorbed following intramuscular injection. In addition, it also crosses the blood placenta barrier and blood-brain barrier.
Sulbactam is a beta-lactamase inhibitor; an enzyme produced by bacteria that destroys the antibiotics.
Class: Antibiotics (Cephalosporin 3rd generation)
Indication / Uses:
• Dermatological infections
• Respiratory tract infections
• Urinary tract infections
• Bone & joint infections
• Pyrexia
• Pneumonia
• Surgical interventions
Dosage and administration / Directions for use:
Dogs : 15 to 50 mg/kg
every 12 to 24 hours by Intramuscular or Intravenous route
Cats : 25 to 50 mg/kg
every 12 hours by Intramuscular or Intravenous route.
Over-dosage / Side effects / Contraindications /Warnings:
If any particles are visible in the vial after reconstitution or dissolving the contents please do not use the solution and return this to the manufacturer for replacement.
Pharmaceutical precautions / Instructions:
Dissolve the contents of the vial in sterile water for injection provided with the pack. Reconstitute and use immediately. Not for human use. For treatment of animals use only.
Substitute: Promicef Tazo 562.5 mg Injection, Intacef Tazo 562.5 mg Injection, CefShot Tazo Injection,
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