Carpade Carprofen 50mg/ml Injection

Carpade carprofen injection is indicated in the treatment of pain & inflammation associated with acute mastitis, respiratory disease, and various kinds of joint pain (osteoarthritis) as well as pain related to surgery or trauma. Carprofen has a significant antipyretic effect in fever associated with mastitis and bovine respiratory diseases.

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Description

Carpade Carprofen 50mg/ml Injection

Manufactured by: Carus Laboratories Pvt. Ltd.

Dosage form: Injection

Presentation: 

10 ml, 15 ml and 30 ml vials

Ingredients & Composition:

Each ml contains:

Carprofen IP                50 mg

Benzyl Alcohol IP       1.04% w/v

Water for Injection IP q.s.

Description: 

Carprofen is a non-steroidal anti-inflammatory drug of Aryl-propionic acid class of NSAIDs. Carprofen is a crystalline compound white in colour, freely soluble in ethanol but practically insoluble in water.

Carprofen is a non-steroidal anti-inflammatory agent which is non narcotic, with characteristic analgesic and antipyretic activity. Like other NSAIDs mechanism of action of carprofen believed to be associated with inhibition of cyclooxygenase activity. Carprofen is a selective inhibitor of cyclooxygenase-COX-2 over cyclooxygenase-COX-1. Cyclooxygenase selectivity would be expected to minimize adverse gastrointestinal & renal effects while effectively reducing o inflammation. The specificity of a particular NSAIDs for COX-2 versus COX-1 may vary from species to species. Carprofen is highly bound to plasma proteins & well distributed in the tissues with the highest concentrations found in kidney and liver followed by fat and muscle. Maximum plasma concentration (Cmax) of carprofen is 10.4 µg/ml after 7.2 hours (Tmax) at 1.4 mg/kg body weight subcutaneously. In cattle elimination half-life ranges from 44.5 to 64.5 hours where as in horses elimination half life ranges from injection. Carprofen has the 23.7 to 43.3 hours after intramuscular longest serum half-life amongst registered NSAIDs used in cattle.

Chemical Name: 6-chloro-a-methyl-9H-carbazole-2-acetic acid

Molecular Formula: C15H12CINO2

Molecular Weight: 273.72 g/mol

Class: NSAIDs

Indication / Uses:

Carprofen is indicated in the treatment of pain & inflammation associated with acute mastitis, respiratory disease, and various kinds of joint pain (osteoarthritis) as well as pain related to surgery or trauma. Carprofen has a significant antipyretic effect in fever associated with mastitis and bovine respiratory diseases.

Dosage and administration:

Cattle: 1.4 mg/kg (1ml/35 kg body weight) by intramuscular, intravenous or subcutaneous route.

Horse: 0.7 mg/kg (1 ml /70 kg body weight) by intravenous route only.

Dog: 4 mg/kg body weight (1 ml/12.5 kg body weight) by subcutaneous route only.

Or as directed by the veterinarian.

Overdoses / Side effects / Contraindications /Warnings:

Carprofen should not be administered with other NSAIDs or steroid. Carprofen must be used with caution in dogs with liver or kidney diseases, dehydration, bleeding deficits or other health problems.

Pharmaceutical precautions / Instructions: 

Store in cool, dry and dark place. Protect from direct sunlight. After first dose withdrawal, use remainder within 28 days.

Safety: Age / Pregnancy:

Carprofen has wide margin of safety in comparison to other NSAIDs. Reproductive toxicity studies in laboratory on animals show no teratogenic or fetotoxic effects. However, in the absence of any specific studies in pregnant cattle, use after a risk/benefit assessment of a veterinary surgeon only.

Withdrawal: 

Milk: Zero hour

Meat: 21 days

Substitute: Carodyl Injection

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