Description

Selaforte Spot-On

Selamectin Spot-On Solution For Dogs And Cats

Manufactured by: SAVA VET / SAVA Healthcare Limited

Doses form: Liquid for topical application

Presentation: 

Small Dogs                                      Single-dose Tube of 0.5 ml
(weighing 5.1 to 10 kg)

Medium Dogs                                Single-dose Tube of 1 ml
(weighing 10.1 to 20 kg)

Large Dogs                                     Single-dose Tube of 2 ml
(weighing 20.1 to 40 kg)

Extra Large Dogs                            Single-dose Tube of 3 ml
(weighing 40.1 to 60 kg)

Cats                                                 Single-dose Tube of 0.75 ml
(weighing 2.6 to 7.5 kg)

Ingredients & Composition:

SELAFORTE spot on solution 12% w/v for

Small Dogs (weighing 5.1 to 10 kg)
Each 0.5 ml contains:
Selamectin EP    60 mg
Butylated Hydroxytoluene IP      0.40 mg
Excipients           q.s.

Medium Dogs (weighing 10.1 to 20 kg)
Each 1 ml contains:
Selamectin EP    120 mg
Butylated Hydroxytoluene IP      0.80 mg
Excipients           q.s.

Large Dogs (weighing 20.1 to 40 kg)
Each 2 ml contains:
Selamectin EP    240 mg
Butylated Hydroxytoluene IP      1.60 mg
Excipients           q.s.

Extra Large Dogs (weighing 40.1 to 60 kg)
Each 3 ml contains:
Selamectin EP    360 mg
Butylated Hydroxytoluene IP      2.40 mg
Excipients           q.s.

Cats (weighing 2.6 to 7.5 kg)
Each 0.75 ml contains:
Selamectin EP    45 mg
Butylated Hydroxytoluene IP      0.60 mg
Excipients           q.s.

Description / Action: 

SELAFORTE (selamectin) Topical Parasiticide is available as ready to use solution in single-dose tubes for topical (dermal) treatment of dogs six weeks of age and older and cats eight weeks of age and older. The content of each tube is formulated to provide a minimum of 6 mg/kg of body weight of selamectin.

Pharmacology / How does Itraconazole work?

Pharmacokinetics

In dogs, after topical spot-on administration selamectin spreads rapidly through the hair coat within the first 24 hours. Only a small part of the administered dose is absorbed through the skin into the bloodstream. After administration, the highest blood levels are attained around 70 hours later. In cats, the amount absorbed into the blood is significantly higher probably due to the thinner cat skin and oral intake after grooming As a consequence, bioavailability is much higher in cats (~75%) than in dogs (-5%).

Excretion runs faster in dogs than in cats. Selamectin is primarily eliminated in the form of the parent molecule in feces and only in trace amounts in urine in both dogs and cats.

Pharmacodynamics

Selamectin, a macrocyclic lactone acts as an agonist of the GABA (gamma-aminobutyric acid) neurotransmitter in nerve cells and also binds to glutamate-gated chloride channels in nerve and muscle cats of invertebrates. In both cases, it blocks the transmission of neuronal signals of the parasites, which are either paralyzed or expelled out of the body or they starve. It also interferes with some parasites’ ability to reproduce by decreasing oviposition or causing improper oogenesis. Macrocyclic lactones are much less toxic to mammals (i.e. macrocyclic lactone does not cross the blood-brain barrier) than to parasites, which allows quite high safety margins for use on livestock and pets.

Class: Endectocide (Macrocyclic Lactone)   

Indication / Uses:

SELAFORTE is recommended for use in dogs six weeks of age or older and cats eight weeks of age and older for the following parasites and indications:

Dogs:

SELAFORTE kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. SELAFORTE is also indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and for the control of tick infestations due to Dermacentor variabilis.

Cats:

SELAFORTE kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. SELAFORTE is also indicated for the treatment and control of roundworm (Toxocara cati) and intestinal hookworm (Ancylostoma tubaeforme) infections in cats.

Dosage:

The recommended minimum dose is 6 mg/kg of body weight.

Administer the entire contents of a single dose tube according to the body weight.

SELAFORTE should be administered on a monthly basis or as recommended by a veterinarian depending on parasitic infestation.

Presentation                    Selamectin concentration (mg)        Administered Volume

SMALL DOGS                                  60 mg                                                             0.5 ml
(Weighing 5.1 to 10 kg)

MEDIUM DOGS                              120 mg                                                           1 ml
(Weighing 10.1 to 20 kg)

LARGE DOGS                                  240 mg                                                           2 ml
(Weighing 20.1 to 40 kg)

EXTRA LARGE DOGS                      360 mg                                                           3 ml
(Weighing 40.1 to 60 kg)

CATS                                                45 mg                                                             0.75 ml
(Weighing 2.6 to 7.5 kg)

For dogs over 60 kg, use the appropriate combination of tubes.

Recommended for use in dogs 6 weeks of age and older and in cats 8 weeks of age and older.

Administration:

Put on gloves
Hold tube with tip facing up
Twist cap
Part hair and apply

Step 1: Immediately before use, Put on gloves. Hold the tube at the crimped end with the cap in an upright position (tip up). The cap should be rotated counterclockwise one full turn. The cap is designed to stay on the tube for dosing and should not be removed. The tube is open and ready for application when a breaking of the seal is felt.

Step 2: The pet should be standing or lying with its back horizontal during application. Part of the fur at the administration site. Place the tube tip vertically against the skin at the base of the skull of the pet.

Step 3: Squeeze the tube and gently apply the entire contents of SELAFORTE directly to the skin at the base of the skull of the pet. Avoid applying an excessive amount of solution that could cause some of the solution to run and drip off of the pet. If a second spot is needed to avoid a runoff, then apply the second spot slightly behind the first spot.

Check the tube to ensure that it is empty. Do not massage the product into the skin. Due to alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the haircoat is wet. Bathing or shampooing the dog 2 or more hours after treatment will not reduce the effectiveness against fleas or heartworm. Bathing or shampooing the cat 2 hours after treatment will not reduce the effectiveness against fleas. Bathing or shampooing the cat 24 hours after treatment will not reduce the effectiveness against heartworm. Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some animals. These effects are temporary and do not affect the safety or effectiveness of the product.

Overdoses / Side effects / Contraindications /Warnings:

WARNINGS: Not for human use. Keep out of the reach of children. In humans, SELAFORTE may be irritating to the skin and eyes. Individuals with known hypersensitivity to Selamectin should use the product with caution or consult a health care professional. Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with the eyes occurs, then flush the eyes copiously with water. In case of ingestion by a human, contact a physician immediately.

Flammable – Keep away from heat, sparks, open flames, or other sources of ignition.

Do not use in sick, debilitated, or underweight animals.

PRECAUTIONS: It is not effective against adult D. immitis and, while the number of circulating microfilariae may decrease following treatment. It is not effective for microfilariae clearance.

ADVERSE REACTIONS: Adverse effects are rare. Some reported adverse event includes vomiting, loose stool or diarrhea with or without blood, anorexia, lethargy, pruritus, fever, salivation, tachypnea, and muscle tremors.

Pharmaceutical precautions / Instructions: 

STORAGE: Store below 30°C. Protect from light and moisture. Keep Out Of Reach Of Children. Hazardous To Humans.

CONTAINER DISPOSAL: Securely wrap the tube in several layers of newspaper and discard it in the trash.

Safety: Age / Pregnancy/ Withdrawal:

Selamectin has been reported safe for use in pregnant and lactating females, breeding males and females, puppies six weeks of age and older, and kittens eight weeks of age and older. Selamectin should not be used in sensitive breeds i.e. collies and related breeds.

Substitute: Selamec Spot On, Ultimat-Select Selamectin Spot On,

Click Here to Buy from Amazon