Ichmune C

Ichmune C capsules or oral solution contains Cyclosporine / ciclosporine which is a potent immunosuppressive agent. Cyclosporine does not impair the hematopoietic system or cell-mediated immunologic responses. Dogs who received 20 mg/kg/day of cyclosporine for 56 days there was no decrease in CD4 and CD8 cells. It is not a corticosteroid or an antihistamine.

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Description

Ichmune C

Brand Name: Ichmune C

Manufactured by: SAVA Vet / SAVA Healthcare Limited

Doses form: Capsules / Oral solution

Presentation: 

ICHMUNE C 100 mg
Blister pack of 5 – 1 x 6 Capsules

ICHMUNE C 50 mg
Blister pack of 5 – 1 x 6 Capsules

ICHMUNE C 25 mg
Blister pack of 5 – 1 x 6 Capsules

ICHMUNE C Oral solution (100 mg/ml)
50 ml bottle along with ferrule

Ingredients & Composition:

Each soft gelatine capsule contains

Cyclosporine USP 100 mg, 50 mg, 25 mg in respective capsules

Oral solution contains Cyclosporine 100 mg/ml

Description / Action: 

Ichmune C capsules or oral solution contains Cyclosporine / ciclosporine which is a potent immunosuppressive agent. It has been shown to work via suppression of T-helper and T-suppressor cells and inhibition of interleukin-2. Cyclosporine does not impair the hematopoietic system or cell-mediated immunologic responses. Dogs who received 20 mg/kg/day of cyclosporine for 56 days there was no decrease in CD4 and CD8 cells. It is not a corticosteroid or an antihistamine.

Ciclosporine is extensively metabolized in the liver by the cytochrome P-450 enzyme system, and to a lesser degree in the gastrointestinal tract and the kidney.

Class: Immunosuppressant

Indication / Uses:

Cyclosporine / cyclosporin / ciclosporin is indicated for the treatment of atopic dermatitis in dogs.

Aids in the treatment of perianal fistulae in dogs. Perianal fistula is thought to be an immune-mediated condition which is a syndrome of inflammation, ulceration and draining sinuses in the perianal region of dogs, particularly in German Shepherds.

Dosage and administration:

5 mg/kg body weight per day

4 to < 8 kg : 25 mg

8 to < 15 kg : 50 mg

15 to < 29 kg : 100 mg

29 to < 36 kg : 150 mg

36 to < 55 kg : 200 mg

For oral administration only.

Canine Atopic Dermatitis:

Cyclosporine – 5 mg/kg once daily either 1 hour before or 2 hours after the meal

Perianal Fistula:

Cyclosporine 8 mg/kg/day as either once or twice daily

Cyclosporine – 1 mg/kg twice daily + Ketoconazole – 10 mg/kg once daily

Overdoses / Side effects / Contraindications /Warnings:

Cyclosporine capsules should be given daily until a satisfactory clinical improvement is seen. It will be generally the case within 4 weeks. Treatment should be discontinued if the response is not obtained within the first 8 weeks of the therapy.

No undesirable effects were observed under recommended treatment in the dogs with a single oral dose of up to 6 times of recommended doses.

There is no specific antidote for cyclosporine overdose. In the case of signs of overdose, the dog should be treated symptomatically. The signs are reversible within 2 months following cessation of treatment.

Vomiting, mucoid or soft faeces, and diarrhoea like gastrointestinal disturbances may occur which are mild and transient and generally do not require the cessation of the treatment. Effects like letharginess or hyperactivity, skin reactions such as verruciform lesions or change of hair coat, red and swollen pinnae, mild to moderate gingival hyperplasia, anorexia, muscle weakness or muscle cramps can be observed but these are rare. These adverse effects are generally get resolved spontaneously after treatment is stopped.

Please inform and consult your veterinarian if you notice any serious effects or other effects not mentioned above.

Pharmaceutical precautions / Instructions: 

Store below 25°C. Keep in a dry and cool place.

Safety: Age / Pregnancy/ Withdrawal:

The safety of cyclosporine has not been studied in breeding male dogs nor in pregnant or lactating female dogs.

Cyclosporine passes the placenta barrier and is excreted via milk, therefore the treatment of lactating bitches is not recommended. Ask your veterinarian if your dog is a breeding animal, so that a risk/benefit assessment can be made.

Always follow the recommendations and do not exceed recommended doses. It has no withdrawal side effects. Cyclosporine is a potent systemic immunosuppressant that may increase the susceptibility to infection and the development of neoplasia.

Systemic use is not recommended in dogs and cats up to 6 months old or in dogs <2 kg or in cats <2.3 kg. Do not use in progressive malignant disorders. Do not give live vaccines during treatment or within a 2-week interval before or after treatment.

Habit forming:  No

Substitute: Atopica

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