Description

Imizet Injection

Manufactured by: Intas Pharmaceuticals LTD.

Dosage form: Injection

Presentation:  Vial of 10 ml

Ingredients & Composition:

Each 1 ml of Imizet injection contains:
Imidocarb dipropionate 120 mg (12%w/v)
Aqueous base q.s.

Description & Mechanism of Action: 

Imizet helps in simplifying the treatment of vector-borne challenges. It is precise, convenient, and potent. Common vector-borne diseases in canine are Babesiosis, Ehrlichiosis, Anaplasmosis, and Hepatozonosis. Babesiosis is caused by intra-erythrocytic (inside RBC) Hemoprotozoa. Ehrlichiosis caused by small, Gram-negative, obligatory intracellular bacteria after which primarily invade leucocytes. Anaplasmosis – Anaplasma phagocytophilum infects white blood cells, Anaplasma platys infects platelets.

Common Symptoms of these vector-borne diseases are  – Fever, Anaemia, Anorexia, Thrombocytopenia, Lethargy, Depression, Weight loss, Emaciation, and Hemoglobinuria, etc.

A simplified protocol for treating mixed protozoan infections. Imidocarb is highly effective against Babesia, Anaplasma, and Ehrlichia. It has excellent compliance for an outstanding response. Imizet comes in a cost-effective multi-dose pack.

Injectable administration keeps the treatment under control. Mean peak plasma concentration is attained in one-hour post-injection. Plasma protein binding ranges between 72 – 92 %. Half-life is 3.5 hours in canines and 10 days in cattle.

Class: Anti-parasitic / Anti-protozoal

Indication / Uses:

Imizet injection is indicated in the treatment and therapeutic management of

• Babasiosis (both treatment and prophylaxis)
• Anaplasmosis
• Canine Ehrlichiosis
• Hepatozonosis

Doses and administration:

Administration:

Recommended by I.M. / S.C. route in dog, cow, buffalo, sheep and goat. In equines strictly recommended by intramuscular route only.

Dosage:

Babesiosis

Treatment
Species	Dosage	Number of Administration
Dog	0.55 ml/ 10 kg	Administer Two doses at 14 days interval
	1.1 ml / 20 kg
	1.65 ml / 30 kg
Cattle & Buffalo	0.5 ml / 50 kg	Single dose
	1.0 ml / 100 kg
Sheep & Goat	0.5 ml / 50 kg	Single dose
Horse	2 ml / 100 kg	Two doses with 24 hours interval may be needed

 

Prophylaxis
Species	Dosage	Number of Administration
Dog	0.55 ml/ 10 kg	A single dose will prevent Babesiosis for up to 4 weeks
	1.1 ml / 20 kg
	1.65 ml / 30 kg
Cattle & Buffalo	2.5 ml / 100 kg body weight	Prophylaxis period for Babesia bovis is up to 4 weeks and for Babesia bigemina up to 8 weeks

Canine Ehrlichiosis / Mixed infection due to Babesiosis and Ehrlichiosis:

Species	Dosage	Number of Administration
Dog	0.55 ml/ 10 kg	Administer Two doses at 14 days interval
	1.1 ml / 20 kg
	1.65 ml / 30 kg

Anaplasmosis:

Species	Dosage	Number of Administration
Dog	0.55 ml/ 10 kg body weight	A single dose
Cattle & Buffalo	2.5 ml / 100 kg body weight	A single dose

Canine Hepatozoonosis:

Species	Dosage	Number of Administration
Dog	0.5 ml/ 10 kg	Repeat after 14 days along with Tetracyclines till recovery
	1.0 ml / 20 kg
	1.5 ml / 30 kg

 

Cats: Not indicated by manufacturer

Overdoses / Side effects / Contraindications /Warnings:

Use in the appropriate dosage.  Most commonly reported adverse effects in dogs include pain, inflammation during the injection. And mild cholinergic signs like salivation, nasal drip, and brief episodes of vomiting may occur post-injection. Must not be given by intravenous route. Avoid use or administration in hepatic and renal patients.

Do not self medicate to avoid side effects and complications.

Pharmaceutical precautions / Instructions: 

Store in a cool and dry place at 2 – 25°C. Protect from light.

Safety: Age / Pregnancy/ Withdrawal:

Safety in puppies, pregnant, lactating, or breeding animals has not been established either reported by the manufacturer. Imidocarb has no reported withdrawal side effects.

Habit-forming:  No. Need to be repeated for prophylaxis or treatment.

Substitute: Babimido Injection, Midocarus Injection, Imicarb Injection,