Description

Midocarus Injection

Imidocarb dipropionate aqueous injection 120 mg/ml

Manufactured/ Marketed by: Carus Laboratories Pvt. Ltd.

Dosage form: Liquid for Injection

Presentation: 

10 ml vial (one vial in a package)

Ingredients & Composition:

Each ml contains:
Imidocarb Dipropionate                120 mg
Benzyl Alcohol (as preservative) IP 2% w/v
Water for Injection IP                   Q.S.

Description: 

Midocarus injection contains imidocarb dipropionate an anti-protozoal. It is used for the treatment and prevention of blood protozoans like Babesia, Anaplasma and Ehrlichia in different animal species like dog, cattle, sheep, goat and horse.

Mode of action:

Imidocarb acts by combining with nucleic acids of DNA in susceptible organisms, causing the DNA to unwind and denature. It is thought that this DNA damage prevents cellular repair and replication. Midocarus (Imidocarb Dipropionate) exerts its action through two mechanisms

i. Interference with the production and/or utilization of polyamines,
ii. Prevention of entry of inositol into the erythrocyte containing the parasite

Pharmacokinetics:

Imidocarb Dipropionate when administered subcutaneously or intramuscularly in lactating and non-lactating cattle reaches its peak level at a mean level of 1.3 ppm equivalents 1 hour after injection. Milk levels peaked at a mean 0.37 ppm Imidocarb Dipropionate equivalents 24 hours post administration. It is excreted slowly from the body mostly via urine. It takes almost 10 days post-dosing for excretion of half the dose.

Class: Antiprotozoal

Indication / Uses:

For treatment of babesiosis in cattle, sheep, horses and dogs.
• Treatment of anaplasmosis in cattle.
• Treatment of ehrlichiosis in dogs.

Dosage and administration:

Treatment:

Cattle: 1 ml per 100 kg bodyweight. Give 2.5 ml per 100 kg of body weight when treating combined infections caused by Anaplasma and Babesia.

Sheep: 0.5 ml per 50 kg bodyweight Horses: 2 ml per 100 kg bodyweight (intramuscular injection is preferred). A single dose will usually result in a full recovery, although treating B. equi infections in horses may necessitate two doses spaced by 24 hours.

Dogs: 0.25 ml per 10 kg bodyweight. For the treatment of combined infections caused by Ehrlichia and Babesia, give two doses of 0.5 ml per 10 kg of body weight spaced 14 days apart.

After one treatment, it is advised to check the blood for the parasite’s presence. If the test is positive, continue your treatment.

Prevention:

Cattle: 2.5 ml per 100 kg bodyweight. A single dose will prevent Babesiosis for up to 4 weeks depending on the severity of the challenge and species involved, Horses: 2 ml per 100 kg bodyweight (intramuscular injection is preferred).

Dogs: 0.5 ml per 10 kg bodyweight. A single dose will prevent Babesiosis for up to 4 weeks.

Sheep: 1 ml per 50 kg bodyweight.

Route of Administration:

For subcutaneous or intramuscular use only. Intravenous administration is totally prohibited.

Overdoses / Side effects / Contraindications /Warnings:

Contra-indicated in animals hypersensitive to Imidocarb Dipropionate & having impaired lung, liver & kidney function. The sign of acute toxicity is generally consistent with anticholinesterase activity of Midocarus (Imidocarb Dipropionate) and included lethargy, salivation, lacrimation, ataxia, tremors and convulsions. Even after a few days, an uncomfortable, inflammatory reaction could be noticed at the injection site. Shortly after injection, vomiting, increased salivation, and nasal discharge are common. Some dog and sheep breeds may experience temporary adverse effects.

When exposed to cholinesterase inhibitors, do not use this product at the same time.

Pharmaceutical precautions / Instructions: 

Store at temperature not exceeding 30°C. Keep out of reach of children. For the use of Registered Veterinarian, Hospital, Laboratory or farm only. Not for human use. For animal treatment only. For veterinary use only.

To be sold by retail on the prescription of a Veterinary Doctor only. Multi Dose Vial: The number of withdrawals should not exceed ten.

Safety: Age / Pregnancy:

Imidocarb’s efficacy and safety in breeding, nursing, or pregnant animals have not been established.

Withdrawal: 

Meat-90 days
Milk-7 days

Substitute: Imizet Injection, Babimido Injection,