Description

Cortalife injection

Isoflupredone Acetate Injectable Suspension

For Intramuscular or Intrasynovial use only

Manufactured by: Safecon Lifesciences (U.K.)

Marketed by: Vet Mankind / Mankind Pharma

Doses form: Suspension for injection

Presentation: 

5m & 10ml vial packed in a carton along with a package insert

Ingredients & Composition:

Each ml contains:

Isoflupredone Acetate IP (Vet)   2 mg

Water for Injections IP                 q. s.

Description: 

Cortalife Injection is a sterile aqueous suspension of Isoflupredone Acetate, having potent glucocorticoid activity. it contains Isoflupredone Acetate, the only corticosteroid approved by USFDA for lactating dairy animals.

Pharmacology/Actions:

The anti-inflammatory potency of Isoflupredone is approximately 17 times that of hydrocortisone (cortisol). The glucocorticoid activity of Isoflupredone is 50 times that of hydrocortisone and 10 times that of prednisolone as measured by liver glycogen deposition in rats.

Cortalife Inj. is intended for intramuscular injection in animals requiring glucocorticoids, anti-inflammatory and/or supportive therapy while, the intra-synovial route is indicated in joint inflammation, tendonitis & bursitis.

Class: Steroid (Glucocorticoid)

Indication / Uses:

• Bovine ketosis
• Parturient paresis or Milk Fever (supportive stress therapy for milk fever before & after calcium therapy)
• Alleviating pain & lameness associated with generalized & acute localized arthritic condition
• Inflammatory conditions such as laminitis, rheumatoid & traumatic arthritis, osteoarthritis, tendonitis, periostitis, tenosynovitis, bursitis & myositis.
• Generalized muscular soreness, stiffness, depression & anorexia resulting from over work, shipping, unusual physical exertion etc.
• Various allergic conditions like dermatitis, conjunctivitis, eczema and anaphylactic reaction.
• Acute hypersensitive reaction – resulting from treatment with a sensitizing drug or exposure to other allergenic agents.
• Overwhelming infections with severe toxicity such as mastitis, pneumonia and in other similar infectious conditions, as a supportive therapy to hasten complete recovery.
• Shock like conditions occurring in association with severe injury, trauma, emergency surgery & elective surgery in poor surgical risks along with standard methods of combating shock

Unique Features:

• No effect on lactation
• No milk with holding required
• Can be administered in pregnancy, does not induce abortion
• Increases glucose levels quickly 10 times more potent than Prednisolone
• Long-acting effect up to 48 hrs of gluconeogenic activity

Dosage and administration:

Cattle & Buffalo: 5 to 10 ml (10 to 20 mg) according to the size of an animal and severity of the condition. The dose may be repeated in 12 to 24 hours, if needed

Horse: 2.5 to 5 ml of (5-20mg).

Sheep & Goat: 0.5 to ml Per 10 kg of B.W. (1 to 2mg Per 10 kg of B.W.)

In infections, characterized by overwhelming toxicity, Cortalife Inj, should be administered only in conjunction with appropriate antibacterial therapy.

Or as directed by the Veterinarian.

By deep intramuscular injection for systemic effect, or into joint cavity, tendon sheath or bursa for local effect. Multiple dose vial. Not to be added to the infusion solutions.

Withdrawal Period:

Meat: 5 days after the last administration.

Milk: 3 days after the last administration.

Safety: Age / Pregnancy/ Withdrawal:

Safe for use in pregnant and lactating female animals and does not cause abortion.

Pharmaceutical precautions / Instructions: 

For more information, refer package insert. Store in a dry place at a temperature not exceeding 30°C. Shake Well Before Use. Protect from light. Not For Human Use. For Veterinary Use Only. Keep out of reach of children. Schedule H Prescription Drug. Not to be sold by retail without the prescription of a Registered Veterinary Practitioner.

Substitute: Isoflud Injection, Predef – 2X injection,

Also see Vetalog Injection, Dexona Injection, Prednisolone Injection,