Prednisolone Injection

Prednisolone crystalline injectable suspension was developed for use in the veterinary field. It has proved to be highly effective in the treatment of acetonemia in cattle (bovine ketosis). Following the injection of prednisolone crystalline suspension, the blood glucose level is restored to normal in short time, appetite and milk yield improves, and circulating ketone bodies return to a normal level. It is 3 to 5 times more active than hydrocortisone, (Natural cortisones) but does not affect mineral balance as that of the other potent corticosteroids.

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Description

Prednisolone Acetate Injectable Suspension

Brand Name: Prednisolone Acetate Injection

Manufactured by: Intervet / MSD Animal Health

Dosage form: Injectable Suspension

Presentation: 

10 ml Vial

Ingredients & Composition:

Each ml of Injectable solution contains
Prednisolone Acetate IP      10 mg
Benzyl Alcohol IP                0.945 % v/v

Description / Action: 

Prednisolone crystalline injectable suspension was developed for use in the veterinary field. It has proved to be highly effective in the treatment of acetonemia in cattle (bovine ketosis). Following the injection of prednisolone crystalline suspension, the blood glucose level is restored to normal in short time, appetite and milk yield improves, and circulating ketone bodies return to a normal level. It is 3 to 5 times more active than hydrocortisone, (Natural cortisones) but does not affect mineral balance as that of the other potent corticosteroids.

Class: Steroid / Corticosteroid

Indication / Uses:

Prednisolone injection is indicated for

  • Treating ketosis in dairy cattle,
  • Rheumatoid arthritis,
  • Bursitis,
  • Inflammatory and allergic conditions in large and small animal in conjunction with appropriate antibiotic or chemotherapeutic agents when indicated.

Dosage and administration:

For Systemic treatment

Cattle:                        50 -100 -200 mg
Calves:                       25-50 mg
Piglets, dogs, cats:    10-30 mg

(Dogs and cats – 0.5 to 1.0 mg/kg body weight as an anti-inflammatory while 1-2 mg/kg body weight for immunosuppression q12-24h)

Route: Injection is given deep into muscle

Frequency: 2 – 4 times if necessary at an interval of 24 hours.

For local treatment

Injection is given in the part involved carefully under strict aseptic conditions.

Injection into Joints & tendon sheaths

Large animals:          25-75 mg or more
Dogs & Cats:             5-20 mg or more

Injection into Bursa

10 – 50 mg or more

Subconjunctival injection

1.25 – 12.5 mg

Retrobulbar injection

2.5-12.5 mg

Infiltration (as in periostitis etc)

10 – 50 mg

Overdoses / Side effects / Contraindications /Warnings:

Contra Indications include diabetes mellitus & osteoporosis.

In such cases, crystalline suspension must not be administered more than twice. Injections into infected tissues are contraindicated.

Use of prednisolone along with NSAIDs increases the risk of GI ulceration.

Pharmaceutical precautions / Instructions: 

The preparation should be shaken well before use, Use fine needle for local therapy. Store protected from light. Not  for human use. For animal treatment only.

Safety: Age / Pregnancy/ Withdrawal:

Do not use in pregnant animals.

Meat – Cattle, Sheep & Goat – 5 days & Pig – 28 days

Milk – 3 days

Habit forming: In case of prolonged use as Immunosuppressive/anti-inflammatory dosage should be tapered slowly.

Substitute:  Predforte

Also See Dexona Injection, Isoflud Injection

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