Description

Cefquinome C4All Injection

Cefquinome for Injection

100 mg and 800 mg Single Dose Vial

Marketed by: Alembic Pharmaceuticals Ltd.

Manufactured by: Aqua Vitoe Laboratories, Solan, HP

Country of Origin: India

Dosage form: Powder for Injection

Presentation: 

100 mg and 800 mg glass vial along with Diluent, Disposable syringe and Needle

Ingredients & Composition:

C4All 100 mg Injection:

Each Vial Contains: (Part A)
Cefquinome Sulphate
Eq. to Cefquinome      100 mg

Solvent for Cefquinome
for Injection 3 ml Ampoule:
Each ml contains (Part B)
Sodium Bicarbonate I.P.      16 mg
Water for Injections I.P.       q.s.

C4All 800 mg Injection:

Each Vial Contains: (Part A)
Cefquinome Sulphate
Eq. to Cefquinome      800 mg

Solvent for Cefquinome for
Injection 24 ml Vial
Each ml contains: (Part B)
Sodium Bicarbonate I.P.      16 mg
Water for Injections I.P.       q.s.

This pack contains free diluent (Part B) along with disposable syringe & needle.

Description / Action: 

Cefquinome C4All Injection is a fourth generation extended -spectrum beta-lactam cephalosporin indicated for the treatment of bacterial infections caused by Gram positive & Gram negative microorganisms including Escherichia coli, Citrobacter spp., Klebsiella spp., Pasteurella spp., Proteus spp., Salmonella spp., Serratia marcescens, Haemophilus somnus, Actinomyces pyogenes, Bacillus spp., Corynebacterium spp., staphylococcus spp., streptococcus spp., Bacteroides spp., Clostridium spp., Fusobacterium spp., Prevotella spp., Actinobacillus spp. and Erysipelothirix rhusiopathiae.

Pharmacodynamics:

Cefquinome is an antibacterial of the cephalosporin group which act by inhibition of cell wall synthesis It is characterized by its broad therapeutic spectrum of activity as a fourth-generation cephalosporin, it combines high cellular penetration and a high stability against beta-lactamase which predict a lower probability for selection. Chemically its Zwitterionic structure also facilitates rapid penetration through porins hydrolysed by cephalosporinases. Compared to other cephalosporins, Cefquinome offers the benefits of higher affinity to Penicillin binding proteins, lower affinity & higher stability to beta- lactamase & improved Penetration into the peri-plasmatic space increasing the intrinsic potency.

Pharmacokinetics:

After intramuscular administration, Cefquinome attains its Cmax of 2.5 mcg/ml in less than an hour. Binding to plasma protein is in the order of 5-15 percent Half-life of Cefquinome is 2.5 hours in cattle with no dose dependency. Cefquinome is metabolized only to a very small extent & exerts its effects in its ready form excretion of parentally administered Cefquinome is predominantly renal while about 5 percent of the dose is also recoverable from faeces.

Class: Antibiotics (Fourth Generation Cephalosporin)

Indication / Uses:

For the treatment of bacterial infections in cattle, buffalo, calf, sheep, goat, pig and camel.

Cattle and Buffalo

1. Respiratory disease: Haemorrhagic septicemia, Pneumonia
2. Mammary gland affections: Mastitis
3. Digital dermatitis,
4. Infectious bulbar necrosis
5. Acute inter digital necrobacillosis
6. Calf scours
7. Bacterial septicemia
8. Bacterial diarrhea

Camel, Sheep and Goat

1. Bacterial Septicemia
2. Pneumonia and Respiratory infections
3. Gastro intestinal infections

Horse

1. Respiratory diseases caused by Streptococcus equi.
2. Bacterial Septicemia
3. Foal Diarrhea

Pig

1. Mastitis-Metritis-Agalactia Syndrome
2. Respiratory disease and mastitis
3. Meningitis, Arthritis and Epidermitis.

Dosage and administration:

Cefquinome is to be administered via intramuscular or intravenous route to cattle, buffaloes, horse and camel at the dose rate of 1 mg per kg body weight every twenty-four hours and in calf, sheep, goat and swine at the dose rate of 2 mg per kg body weight once daily.

Route(s):

For intramuscular and Intravenous Use

Direction for Reconstitution:

Shake the vial to loosen the powder. Reconstitute the solution for injection by adding the whole contents of the solvent for Cefquinome for Injection. After reconstitution, shake the vial well before use. Ensure that the solution should be clear without any visible particles.

Overdoses / Side effects / Contraindications /Warnings:

Hypersensitivity to cephalosporins is rare, however, Cefquinome should not be administered to animals which are known to be hypersensitive to beta-lactam antibiotics.

Pharmaceutical precautions / Instructions: 

Store protected from light below 25°C.
Do not freeze.
Keep the medicine out of reach of children.
The reconstituted solution should be used immediately after Preparation.
Not for human use; for animal treatment only.
Schedule H Prescription Drug Caution: Not to be sold by retail without the prescription of a Registered Medical Practitioner.

Safety: Age / Pregnancy/ Withdrawal:

No information is available with the product.

Withdrawal Period:

Milk-36 hours
Meat-2 days

Substitute: Pooch Nome Tablets, Inj. Cobactan (2.5% or 25mg/ml),