Description

ZUBION Injection

ZUBION Buparvaquone Injection

Manufactured/Mktd by: Intas Pharmaceuticals LTD.

Doses form: Liquid for Injection

Presentation: 

2 ml, 20 ml and 30 ml vial

Ingredients & Composition:

Each ml contains:
Buparvaquone IP        50 mg
Sorbitan mono oleate IP      100 mg
(As preservative)
Oil Base             Q.S.

Description / Action: 

ZUBION injection is a ready to use solution for intramuscular injection containing Buparvaquone, a second generation hydroxynapthaquinone, which acts by the inhibition of mitochondrial electron transport system of the protozoa.

Class: Second Generation Hydroxynapthaquinone / Anti-protozoal

Indication / Uses:

ZUBION Injection is indicated for the treatment of theileriosis like East coast fever, Corridor disease, Tropical theileriosis etc in cattle caused by Theileria annulata, T. parva (bovis), T. parva (lawrence), T. mutans and T. orientalis (sergent). It is active against the schizont and piroplasm stages of theileria species and can be used in the incubation period of the disease or when clinical signs are apparent. Treatment should be given to clinically affected animals and sub-clinical or in-contact animals.

Dosage and administration:

2.5 mg per kg or 1 ml per 20 kg body weight. In severe cases the dose may be repeated within 48-72 hours after the initial injection. Intramuscular injection into the neck muscle is recommended by taking standard aseptic precautions. Not more than 10 ml should be injected in single site. When the required dose is more than 10 ml it should be injected in separate sites of the neck.

Relapses may occur in cases of severe Theileriosis, requiring further treatment with ZUBION Recovered animals will develop homologous immunity. However, any subsequent infections with antigenically unrelated species or strains of Theileria may require further treatment with ZUBION. In case of an outbreak of Theileriosis, prompt dipping of all animals at risk must be an integral part of disease control programme. For the control of secondary infections supportive antibacterial chemotherapy may be needed. Attention to nutrition is recommended as an aid to convalescence. Severely affected animals should not be subjected to stress, e.g. walking over long distance, dipping etc. Anaemia is a frequent characteristic of Theileria spp infections, particularly those caused by T. annulata, T. sergenti and T mutans. A supportive therapy for correcting this anaemia should be considered. Theileriosis has severe depressant effects on the immune system. Therefore, it is recommended that any vaccination be delayed until the complete recovery from disease.

Over-dosage / Side effects / Contraindications /Warnings:

It must not be given by intravenous or subcutaneous routes.

Localised, painless, odematous swelling may occasionally be seen at the injection site.

Pharmaceutical precautions / Instructions: 

Store protected from light and at a temperature not exceeding 25°C. Keep medicines away from children.

Safety: Age / Pregnancy/ Withdrawal:

Limited information is available.

Withdrawal Period: Milk-48 hrs/ Meat-42 days.

Substitute: Inj. Butalex, Inj. Butazyd, Inj. Butasun, Inj. Trucare, Inj. Bupralex, Inj. Thylocure,