Description

Vetdox Injection

Doxycycline Injection for Dogs Cats

Manufactured by: Corise Canine Care / Corise Healthcare Pvt. Ltd.

Dosage form: Powder for Injection

Presentation: 

100 mg glass vial

Ingredients & Composition:

Each glass vial contains lyophilized dry powder which is equivalent to
Doxycycline  USP 100 mg

Description / Action: 

Vetdox Injection contains doxycycline which a time dependent antibiotic of tetracycline class. It inhibits protein synthesis at 30 S ribosomal subunit.

Spectrum of Action of Doxycycline

Gram-negative bacteria
Acinetobacter species, Klebslella species, Escherichla gonorhea, Vibrio cholerae, Enterobacter aerogenes

Gram-positive bacteria
Bacillus anthracis, Strptococcus pneumniae

Anaerobes
Clostridium species, Propionibacterium acnes

Parasites
Plasmodium falciparum, Entamoeba species

Other bacteria
Rickettsia, Chlamydia, Trachomatis

Class: Antibiotics / Tetracycline

Indication / Uses:

Clinical studies have shown that Vetdox is clinically successful in the treatment of a number of infections caused by sensitive strains of Gram-positive and Gram-negative bacteria as well as some other microorganisms.

• Tick borne diseases like Lyme disease, ehrlichiosis & toxoplasmosis
• Respiratory tract infections – Pneumonia and lower respiratory tract infections due to susceptible strains of Streptococcus pneumoniae,  Treatment of chronic bronchitis, sinusitis etc.
• Urinary tract infections caused by susceptible strains of Klebsiella species, Enterobacter species, Escherichia coli, Streptococcus faecalis, Chlamydia along with many other canine bacterial infections.

Dosage and administration:

5-10 mg/kg body weight once a day. For intravenous administration only.

This reconstituted solution is to be given intravenously. Rapid administration is to be avoided.

Parenteral therapy should only be used when oral therapy is not indicated. As soon as feasible, oral medication should be started.

Preparation of solution:

• To prepare a solution containing 10mg/ml, the contents of the vial should be reconstituted with 10 ml of sterile water for injection IP.

• Each 100 mg of Doxycycline (i.e withdraw entire solution from the 100 mg vial) is further diluted with 100 to 1000 ml of the intravenous solutions:
0.9% Sodium chloride Injection IP
5% Dextrose Injection IP

As a result, the necessary concentrations of 0.1 to 1 mg/ml will be achieved. It is not advised to use concentrations lower than 0.1 mg/ml or more than 1 mg/ml.

Stability of the Solution:

Vetdox is stable for 4 hours in solution when diluted with sodium chloride injection or 5% Dextrose injection, to concentrations between 1 mg/ml and 0.1 mg/ml and stored at 25°C. Vetdox in these solutions is stable for 4 hours but must be protected from direct sunlight during storage and infusion.

Solutions must be used within these time periods or discarded. When diluted with or Dextrose 5% in infusion of the solution (ca 1 mg/ml) or lower concentrations (not less than 0.1 mg/ml) must be completed within 4 hours after reconstitution to ensure adequate stability.

Overdoses / Side effects / Contraindications /Warnings:

Gastrointestinal Adverse Reactions:

Nausea, anorexia, diarrhoea, vomiting, enterocolitis, dysphagia, and inflammatory lesions (with monilial overgrowth). These reactions have been caused by both the oral and parenteral administration of tetracyclines.

Skin Adverse Reactions:

Hypersensitivity Reactions

In case of rapid administration and over prolonged periods of time, thrombophlebitis may result.

Pharmaceutical precautions / Instructions: 

Store in a cool and dry place. Protect from heat and direct sunlight. Do not freeze.

Strictly for veterinary use / animal treatment.

Protect the solution from direct sunlight during infusion. Solutions must be used within this time period or discarded.

Safety: Age / Pregnancy/ Withdrawal:

Doxycycline should not be administered to pregnant animals.

Substitute: Injection Doxypet Mono, Doxysil Tablets, Injection and Oral Suspension,