Description

IVERHART PLUS Tablets

Ivermectin/Pyrantel Flavored Chewable for Dogs

Manufactured by: Virbac AH

Dosage form: Tablets

Presentation: 

Available in 3 dosage strengths for different weights of dogs.

Box of 6 tablets (packed 10 boxes per display box).

Small:        Up To 25 lbs
Medium:   26-50 lbs
Large:        51-100 lbs

Ingredients & Composition:

Large       51-100 lbs
Each flavored chewable contains
Ivermectin                 272 mcg
Pyrantel as pamoate salt             227 mg

Medium   25-50 lbs
Each flavored chewable contains
Ivermectin                 136 mcg
Pyrantel as pamoate salt             114 mg

Small       26-25 lbs
Each flavored chewable contains
Ivermectin                 68 mcg
Pyrantell as pamoate salt            57 mg

Highly palatable (96%), pork liver flavoured chewable tablet

Description / Action: 

Iverhart Plus contains ivermectin and pyrantel as pamoate salt. It provides an effective protection against roundworms, heartworms, and hookworms.

Heartworms are transmitted when a mosquito that has bitten an infected dog goes on to bite a healthy dog.  Heartworms live in the major blood vessels between the heart and lungs of infected dogs. Administration of one tablet monthly protects your dog from heartworm disease and treats and controls roundworms and hookworms.

Class: Dewormer / Parasiticide

Indication / Uses:

Indicated for use in dogs to
• Prevent canine heartworm disease (it eliminates tissue stage of heartworm larvae or Dirofilaria immitis for 30 days after infection
• Treatment and control of round worms or ascarids (Toxascaris leonina, Toxocara canis) and
• Treatment and control of hookworms (Ancylostoma braziliense, Uncinaria stenocephala, Ancylostoma caninum etc).

Dosage and administration:

For oral administration at monthly intervals at the recommended minimum 6 mcg/kg or 2.72 mcg/lb of ivermectin and 5 mg/kg or 2.27 mg/lb of pyrantel.

Recommended dosing schedule:

Dog Weight	Flavored Chewable Per Month	Ivermectin Content	Pyrantel Content
Up to 25 lbs	1	68 mcg	57 mcg
26 to 50 lbs	1	136 mcg	114 mcg
51 to 100 lbs	1	272 mcg	227 mcg

Use the appropriate combination for dogs over 100 lbs.

This schedule is helpful in both prevention of Dirofilaria or canine heartworm disease and for the treatment + control of intestinal roundworms and hookworms.

Directions for use:

Only one tablet at a time should be removed from the foil-backed blister card. It can either be offered to the dog by hand or may be added intact to a small amount of dog food. It can also be placed in the back of the dog’s mouth for forced swallowing.

Take care of complete consumption 0f dose, and after administration treated animals should be observed for a few minutes to ensure if part of the dose is not lost or rejected. In case of suspected loss of the dose, redosing is recommended.

Frequency:

During the period of the year when mosquitoes (vectors) are active and potentially carrying infective heartworm larvae; it should be given at monthly intervals.

Within 30 days after the dog’s first exposure to mosquitoes give the initial dose and final dose within a month after the last exposure.

In case if you are replacing another heartworm preventive medicine then first dose must be given within 30 days of the last dose of the former medication.

Efficacy of ivermectin can be reduced in case administration gap exceeds 30 days. To maintain optimal performance, administer once in a month on or about the same day of the month. If the treatment is delayed, whether by a few days or many, immediate treatment and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms. Clients should be advised to take measures to prevent reinfestation with intestinal parasites.

EFFICACY:

Oral administration of the recommended dose and regimen is effective against the larval stage of Dirofilaria immitis for a period of 30 days after infection and, as a result, prevents the development of the adult stages of heartworm.

Species: For Oral Use in Dogs Only.

Benefits:

• Cost-effective formula and Affordable heartworm and internal parasite protection
• Easy Dosing: 96.3% acceptance rate^*
• Bacon flavor that dogs love
• Beef-free—safe for dogs with beef allergies
• The only ivermectin-based, bacon-flavored chew
• Great for multi-dog households

Over-dosage / Side effects / Contraindications /Warnings:

Before starting a preventive program, all dogs should be tested for heartworm infestation because Iverhart is not effective against adult heartworms and infected dogs must be treated before starting preventive dosing.

Clinical trials have rarely shown vomiting or diarrhoea within 24 hours of dosing with ivermectin/pyrantel. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.

Commonly encountered adverse reactions following the ivermectin administration include staggering, depression/lethargy, ataxia, vomiting, diarrhoea, hypersalivation, anorexia, mydriasis and convulsions.

Pharmaceutical precautions / Instructions: 

Keep out of the reach of kids/children. Contact a medical professional immediately in case of accidental ingestion by human beings.

Store at 20°C – 25°C, excursions permitted between 15°C – 30°C. Protect product from light.

Use product on or prior to its expiry date. Dispose of or return unused tablets.

Safety: Age / Pregnancy/ Withdrawal:

Research studies with ivermectin shows that certain Collie breed dogs are more sensitive to the effects of ivermectin at elevated dose levels of greater than 16 times of the normal level of 6 mcg/kg in comparison to the dogs of other breeds. At elevated dosage, sensitive dogs showed adverse reactions like ataxia, mydriasis, tremors, depression, paresis, drooling, excitability, recumbency, stupor, coma and death. lvermectin showed no signs of poisoning at ten times (60 mcg/kg) of the recommended dose (6 mcg/kg) in sensitive Collies. Outcome of these trials and bioequivalency studies, supports the safety of ivermectin products in dogs, including Collie breed, when used as recommended.

Both lvermectin and pyrantel has shown a wide margin of safety at the suggested dose levels in pregnant or breeding bitches, stud dogs and puppies aged six weeks or more. During clinical trials intended for safety many commonly used  dips, anthelmintics, flea collars, shampoos, antibiotics, steroids preparations and vaccines had been administered with ivermectin and pyrantel in a heartworm disease prevention programme.

In one clinical trial in puppies suffering from parvovirus infection there was a marginal reduction in the efficacy against intestinal nematodes, possibly due to a change in intestinal transit time.

IVERHART PLUS is well tolerated and there are rare reports of digestive or neurological side effects following use in healthy dogs.

Substitute: Updating Soon

Also See Interceptor Plus, KIWOF HART Tablets, Heartgard, Ipraz Tablets,