Description

GRAPITAIL Tablets

Grapirant Tablets For Dogs

Manufactured by: Vivaldis Animal Health

Dosage form: Tablets

Presentation: 

Each box contains 10 blisters
Each blister contains 6 tablets

Ingredients & Composition:

Each chewable tablet contains:
Grapiprant 100 mg
Excipients          q.s.
Hickory smoked flavor

Description / Action: 

Grapitail Tablets contain grapiprant a non-Cox inhibiting NSAID for the management of chronic pain in dogs. GRAPITAIL has a unique mechanism of action. It is a first-line choice in the management of Canine osteoarthritis. It inhibits EP4 that is one of the target receptors for PGE2 which is the most abundant PG in synovia & is a key mediator of inflammation and pain.

Blocking of EP4 results in reducing the production of proinflammatory mediators, Reduces vasodilation, and Decreases vascular permeability (swelling).

It does not pose possible complications like Gastrointestinal Damage (Bleedings), Increased blood pressure, Renal Failure and Stroke-Myocardial Problems which are caused by Long-term use of COX Inhibitor NSAIDS like meloxicam, carprofen, firocoxib etc.

Class: NSAIDs (Non-steroidal anti-inflammatory drug)

Indication / Uses:

Indicated for the control of pain and inflammation associated with osteoarthritis in dogs.

Benefits:

• Novel drug for osteoarthritic pain
• FDA approved in 2016 for Dogs
• Belongs to Piprant class of drugs
• Non-cyclooxygenase (COX)- inhibiting NSAID
• Prostaglandin Receptor Antagonists (PRA)

Benefits of grapiprant:

First-In-Class Non-Cox Inhibiting NSAID
• Grapiprant is a prostaglandin receptor antagonist (PRA). It is a non-COX Inhibiting NSAID specifically blocking the EP4 receptor. EP4 is the primary mediator of canine OA (osteoarthritis) pain and inflammation”

Use for All Stages of OA
• Grapiprant can be used for all stages of canine osteoarthritis, from the earliest clinical signs, and can be used as long as needed.

Safe to Use Daily
• Grapiprant is safe to use daily to deliver effective canine osteoarthritis pain management also in early stage. Suitable for use in puppies older than 9 months of age.

Targeted Pain Relief
• Blocks the EP4 receptor, which is the main mediator of pain and inflammation in associated with OA in dogs.

The Lower side effects
• Reduces impact on Gl, Kidney and liver homeostasis

Improved mobility
• Reduces pain, inflammation & improves quality of life.”

Dosage and administration:

2 mg/kg once daily

It should be given empty stomach (eg, in the morning) and at least one hour before the next meal, once daily at a target dose of 2 mg per kg body weight.

Route: For oral administration only

Species: Dogs only. Not recommended for cats.

Over-dosage / Side effects / Contraindications /Warnings:

In some cases, transient signs of GI disturbances can be observed after administration. Do not use in dogs less than 9 months of age and 3.6 kg body weight.

Pharmaceutical precautions / Instructions: 

Store in a cool and dry place. Keep away from light and moisture. Keep out of reach of children and pets. Not for human use. For treatment of animals only.

To be sold by retail on the prescription of a Registered Veterinary Practitioner.

Safety: Age / Pregnancy/ Withdrawal:

It should not be given to pregnant, lactating or breeding dogs. Studies have suggested the safety of long-term oral administration (even with 25 times the recommended dose) of Grapiprant to dogs.

Substitute: Galliprant Tablets,

Firocoxib tablets: Firotail Tablets,