NUMELVI Tablets
NUMELVI Tablets contain Atinvicitinib an advanced veterinary dermatology medicine formulated to control itching and inflammation associated with allergic skin disease in dogs. Atinvicitinib selectively inhibits JAK1-mediated cytokine pathways responsible for pruritus and allergic inflammation.
Description
NUMELVI Tablets
Atinvicitinib Tablets
Fast-acting JAK1 inhibitor for allergic dermatitis & pruritus in dogs
Manufactured/Marketed by: Merck Animal Health/ MSD
Country of Origin: Formulated in Austria
Dosage form: Scored oral tablets
Presentation:
Available in four tablet strengths: 4.8 mg, 7.2 mg, 21.6 mg and 31.6 mg
Available in 30-count and 90-count bottles. Tablets are marked as S, M, L, or XL according to strength.
Ingredients & Composition:
Atinvicitinib 4.8 mg/ 7.2 mg/ 21.6 mg / 31.6 mg
Classification:
Selective JAK1 inhibitor / Immunomodulator
Description / Action:
NUMELVI Tablets contain Atinvicitinib an advanced veterinary dermatology medicine formulated to control itching and inflammation associated with allergic skin disease in dogs. Atinvicitinib selectively inhibits JAK1-mediated cytokine pathways responsible for pruritus and allergic inflammation.
Key Benefits:
Rapid relief from itching and allergic irritation
Controls inflammation associated with canine atopic dermatitis
Helps reduce scratching, redness, and skin trauma
Non-steroidal antipruritic therapy
Convenient once-daily administration
More selective for JAK1 compared with JAK2 and JAK3 pathways
NUMELVI is not a corticosteroid or antihistamine.
Indication / Uses:
NUMELVI tablets are indicated for:
Allergic dermatitis in dogs
Atopic dermatitis
Severe pruritus (itching)
Flea allergy dermatitis
Food allergy dermatitis
Contact dermatitis
Chronic allergic skin conditions
Recommended for dogs 6 months of age and older.
Dosage and administration:
0.8–1.2 mg/kg orally once daily with food
Dosage chart for NUMELVI Atinvicitinib Tablets:
Body Weight | Recommended Tablet |
2–2.9 kg | ½ × 4.8 mg |
3–4.3 kg | ½ × 7.2 mg |
4.4–6 kg | 1 × 4.8 mg |
6.1–9 kg | 1 × 7.2 mg |
9.1–13.5 kg | ½ × 21.6 mg |
13.6–19.3 kg | ½ × 31.6 mg |
19.4–26.5 kg | 1 × 21.6 mg |
26.6–39.5 kg | 1 × 31.6 mg |
39.6–54 kg | 1½ × 31.6 mg |
54.1–79 kg | 2 × 31.6 mg |
Administer orally once daily with food.
Overdoses / Side effects / Contraindications /Warnings:
Common Side Effects: Vomiting, Diarrhea, Otitis externa, Lethargy, Anorexia, Urinary tract infection, Flatulence and bloating, Increased urination.
Warnings: Increased susceptibility to infections and demodicosis risk. Immunosuppression and possible neoplastic conditions reported with JAK inhibitors. Use cautiously with glucocorticoids, cyclosporine, or other immunosuppressive agents.
Contraindications:
Dogs below 6 months of age. Dogs with serious infections.
Use cautiously in immunocompromised dogs.
Pharmaceutical precautions / Instructions:
Administer with food for improved absorption. Store at 15–30°C.
Keep out of reach of children and animals. Wash hands after handling tablets. Avoid accidental overdose.
Safety: Age / Pregnancy / Withdrawal:
Safe only for dogs older than 6 months.
Safety has not been established in breeding, pregnant, or lactating dogs.
Withdrawal:
Not applicable for companion animals.
Substitute: Apoquel Tablets,
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