Description

NUMELVI Tablets

Atinvicitinib Tablets

Fast-acting JAK1 inhibitor for allergic dermatitis & pruritus in dogs

Manufactured/Marketed by: Merck Animal Health/ MSD

Country of Origin: Formulated in Austria

Dosage form: Scored oral tablets

Presentation:

Available in four tablet strengths: 4.8 mg, 7.2 mg, 21.6 mg and 31.6 mg

Available in 30-count and 90-count bottles. Tablets are marked as S, M, L, or XL according to strength.

Ingredients & Composition:

Atinvicitinib       4.8 mg/ 7.2 mg/ 21.6 mg / 31.6 mg

Classification:

Selective JAK1 inhibitor / Immunomodulator

Description / Action:

NUMELVI Tablets contain Atinvicitinib an advanced veterinary dermatology medicine formulated to control itching and inflammation associated with allergic skin disease in dogs. Atinvicitinib selectively inhibits JAK1-mediated cytokine pathways responsible for pruritus and allergic inflammation.

Key Benefits:

Rapid relief from itching and allergic irritation
Controls inflammation associated with canine atopic dermatitis
Helps reduce scratching, redness, and skin trauma
Non-steroidal antipruritic therapy
Convenient once-daily administration
More selective for JAK1 compared with JAK2 and JAK3 pathways
NUMELVI is not a corticosteroid or antihistamine.

Indication / Uses:

NUMELVI tablets are indicated for:

Allergic dermatitis in dogs
Atopic dermatitis
Severe pruritus (itching)
Flea allergy dermatitis
Food allergy dermatitis
Contact dermatitis
Chronic allergic skin conditions

Recommended for dogs 6 months of age and older.

Dosage and administration:

0.8–1.2 mg/kg orally once daily with food

Dosage chart for NUMELVI Atinvicitinib Tablets:

Administer orally once daily with food.

Overdoses / Side effects / Contraindications /Warnings:

Common Side Effects: Vomiting, Diarrhea, Otitis externa, Lethargy, Anorexia, Urinary tract infection, Flatulence and bloating, Increased urination.

Warnings: Increased susceptibility to infections and demodicosis risk. Immunosuppression and possible neoplastic conditions reported with JAK inhibitors. Use cautiously with glucocorticoids, cyclosporine, or other immunosuppressive agents.

Contraindications:

Dogs below 6 months of age. Dogs with serious infections.
Use cautiously in immunocompromised dogs.

Pharmaceutical precautions / Instructions:

Administer with food for improved absorption. Store at 15–30°C.

Keep out of reach of children and animals. Wash hands after handling tablets. Avoid accidental overdose.

Safety: Age / Pregnancy / Withdrawal:

Safe only for dogs older than 6 months.
Safety has not been established in breeding, pregnant, or lactating dogs.

Withdrawal:

Not applicable for companion animals.

Substitute: Apoquel Tablets,