Description

Nobivac Lepto

Brand Name: Nobivac Lepto

Manufactured by: MSD Animal Health (Intervet)

Dosage form: Injection

Presentation: 

1.0 ml (1 Dose) x 10 Vials – Box

Ingredients & Composition:

Nobivac Lepto is an inactivated vaccine. Each ml contains:

Leptospira interrogans serotype Canicola strain Ca-12-000 at least 957 units/ml
Leptospira icterohaemorrhagiae strain 820k at least 625 units/ml

Description / Action: 

Nobivac Lepto is a bivalent, inactivated vaccine for the immunization of dogs against leptospirosis caused by Leptospira canicola and Leptospira icterohaemorrhagiae. Nobivac Lepto is a liquid vaccine that can be used for reconstitution of freeze-dried Nobivac canine vaccines (eg. Nobivac DHPPi + Lepto 1). This combination of vaccines allows vaccination for up to 6 different infectious diseases in one go. Nobivac Lepto can be used alone without mixing with other compatible vaccines.

The majority of the cases of Leptospirosis are chronic or subclinical in nature but can be acute and potentially fatal in dogs. Infected dogs can harbour the bacteria in their kidneys. In many chronic cases of leptospirosis, the immune system is unable to clear the infection completely and remains persistent. This results in the shedding of the bacteria in the urine. Such Infected dogs can be a potential source of infection for other dogs and can shed Leptospira in this way for months. The risk of leptospirosis also extends to humans due to its zoonotic potential. Nobivac Lepto inhibits renal shedding to reduce the risk of zoonotic spread.

Class: Biologicals / Dog Vaccine

Indication / Uses:

The leptospirosis vaccine is shown to be effective prevention against disease, mortality, and leptospiruria caused by Leptospira serovars. Nobivac Lepto is indicated for active immunization of healthy puppies and dogs against

• Leptospirosis caused by Leptospira icterohaemorrhagiaeand Leptospira canicola of Leptospira interrogans.
• Clinical leptospirosis, and against becoming renal carriers after challenge.
• Helps in the protection against liver dysfunction and thrombocytopenia caused by Leptospira organism.
• Aids in the prevention of leptospiruria associated with  pomona.

Dosage and administration:

Allow the vaccine to reach room temperature. Inject 1ml of Nobivac Lepto subcutaneously using aseptic precautions. It can also be used to reconstitute Intervet’s freeze-dried vaccines, Nobivac Puppy DP and Nobivac DHPPi.

Vaccination Programme:

Nobivac Lepto is indicated for a basic vaccination schedule. Primary or First vaccination at the age of 8 – 9 weeks, followed by a booster at 12 weeks of age. Annual revaccination with 1 dose is recommended

Overdoses / Side effects / Contraindications /Warnings:

A mild anaphylactic – type hypersensitivity reactions following administrations are rare but as with all vaccine may occasionally be encountered. In such an event, administration of an antihistamine, corticosteroid, or adrenaline by the most immediate or subcutaneous route may be indicated. This type of reaction can occur after the injection of any foreign protein and is, in most cases, self – limiting. Only healthy dogs should be vaccinated, and an adequate clinical examination should be made prior to inoculation.

Sterile injection equipment should be used for administration. Care should be taken to avoid contamination of a vaccine with traces of disinfectant or spirit.

A diffuse swelling up to 5mm in diameter following subcutaneous administration may be observed at the site of injection. Sometimes this swelling may be painful and hard and may last up to 3 days post-injection.

A transient rise in body temperature in some rare cases may occur.

Pharmaceutical precautions / Instructions: 

The vaccine must be stored in the original container between 2 °C and 8 °C. Once reconstituted use within 30 minutes. Do not freeze.  Avoid prolonged or repetitive exposure to high ambient temperatures.  Allow the vaccine to gradually reach at 20 °C to 25 °C or room temperature prior to use.  Protect from direct sunlight. Do not open and reconstitute the vaccine until ready to start the vaccination.

Accidental self-injection may lead to severe allergic reactions. Consult a physician.

Keep biologicals out of reach of children.  Although the vaccine has been extensively tested under a large variety of conditions, failure thereof may ensue as a result of a wide range of reasons. If vaccination failure is suspected, seek veterinary advice, and notify the registration holder.

Safety: Age / Pregnancy/ Withdrawal:

Recommended for use in healthy dogs 8 weeks of age or older.  Proven safe and well-tolerated in multiple studies. Safety confirmed in a 749-dog field study.^. Well tolerated on subcutaneous administration. Proven safe across a variety of breeds and ages. The withdrawal period is not applicable. Always follow the recommended dose.

Habit forming: No, But Protocol should be followed according to the guidelines for better immunity and good results.

Substitute: Updating soon