Description

Duromect Injection

Manufactured / Mktd by: Zydus AHL

Dosage form: Injectable Solution

Presentation: 

10 ml & 50 ml vials

Ingredients & Composition:

Each ml contains:

Doramectin                   10 mg
Benzyl Alcohol IP       20 mg
(As preservative)
Oily base             Q.S.

Description / Action: 

DUROMECT (Doramectin) injection is a long-acting broad-spectrum parasiticide for dogs, cats, cattle, sheep, goats and swine. Duromect is a low-volume injection which effectively controls a wide range of roundworms of sheep, goats, cattle, and pigs as well as arthropod parasites of cattle, sheep, and pigs, which impair their health and productivity.

Doramectin is a fermentation-derived product like ivermectin. It is obtained from fermentations of a genetically altered strain of Streptomyces avermitili (avermectin class).

Doramectin modulates chloride ion channel activity in the nervous system of nematodes and arthropods like other avermectins by binding to receptors that increase membrane permeability to chloride ions. Blockage of chloride ion channel inhibits the electrical activity of nerve cells in nematodes and muscle cells in arthropods, and causes flaccid paralysis and death of the parasites. Doramectin has a wide margin of safety in animals when used as recommended because it does not readily penetrate the mammalian CNS.

Class: Parasiticide

Indication / Uses:

CATTLE:

DUROMECT is a long-acting injectable solution indicated for the treatment and control of the gastro intestinal roundworms, parafilaria, screwworms, sucking lice, mange mites and single host ticks in cattle.

SHEEP AND GOATS:

DUROMECT is a long-acting injectable solution indicated for the treatment and control of the gastrointestinal roundworms, parafilaria, screwworms, sucking lice, mange mites and single host ticks.

SWINE:

DUROMECT injectable solution controls lung worms (Metastrongylus spp) and roundworms (Oesophagostomum dentatum, Ascaris suum, Trichuris suis and Oesophagostomum quadrispinulatum). It also kills lice and sarcoptic mange mites on pigs.

Dogs & Cats:

Canine and Feline Demodecosis (Literature warns Use)

Dosage and administration:

DUROMECT is a pale yellow ready-to-use sterile solution containing 1 % w/v (10 mg/ml) doramectin. It is formulated to deliver the recommended dosage for cattle, sheep and goats (200 µg/kg body weight) when given by either intramuscular or subcutaneous injection at the rate of 1 ml/50 kg body weight and for swine 300 µg/kg body weight) when given by intramuscular injection at the rate of 1 ml/33 kg body weight.

CATTLE:

Administer Duromect at a dosage rate of 200 µg doramectin/kg (1 ml/50 kg body weight) by IM or SC route.

SHEEP AND GOATS:

Administer at a dosage rate of 200 µg/kg doramectin (1 ml/50 kg) body weight by IM or SC route.

SWINE:

Administer at a dosage rate of 300 µg doramectin/kg (1 ml/33 kg) body weight by IM route.

Dogs & Cats:

In case of generalized canine and feline demodecosis @ 600 µg/kg by SC route. Safe for use in breeds sensitive for ivermectin like Collie.

Overdoses / Side effects / Contraindications /Warnings:

Sheep and goats should be vaccinated against enterotoxemia or pulpy kidney disease before treatment. Vaccination against broad spectrum Clostridium infections (e.g. black quarter, malignant edema) is strongly recommended in cattle, sheep and goats.

Pharmaceutical precautions / Instructions: 

Store away from direct sunlight in a dry place below 30°C. Always keep out of reach of uninformed persons and children.

The number of withdrawals should not exceed ten.

Safety: Age / Pregnancy/ Withdrawal:

Withdrawal Period: Milk: 7 days, Meat: 28 days.

Substitute: Dectomax Injection

Also See Ivomec Injection, Hitek Injection