Dyntec Spol S.R.O.
Dosage form: Injection
1 x 6 ml, 1 x 5 ml, 6 x 5 ml
All sizes may not be available / marketed.
Ingredients & Composition:
1.0 ml of Canglob DHLaPPi contains:
Canine parvo virus immunoglobulins / antibodies NLT
Canine parainfluenza immunoglobulins NLT 64 HIU
Laryngotracheitis and infectious hepatitis Immunoglobulins
NLT 160 VNAb50
Canine Distemper virus immunoglobulins / antibodies
NLT 160 VNAb50
- Hemagglutination-inhibition titre, in a sample dilution, when 50% frequency
of complete hemagglutination evoked by virus in a given work dose
VNAb - Titre
of virus-neutralization antibodies in a sample dilution, when 50% of cytopathic
changes evoked by virus in a given work dose are subdued)
Thiomersal NMT 0.1 mg,
Diluting medium 1.0 ml.
Description / Action:
Canglob DHLaPPi is liquid suspension
containing purified hyperimmune immunoglobulins / antibodies (IgY) against infectious
hepatitis, infectious laryngotracheitis of dogs, parvovirus of dogs,
parainfluenza of dogs and canine distemper to ensure passive immunization of dogs, for
therapeutic / treatment and prophylactic use. Disease / virus / pathogen
specific antibodies facilitate to prevent the development of disease or if they
already run – to alleviate its course. Canglob DHLaPPi is used
for the treatment and prophylaxis of dogs as well as first choice in cases when
a causative agent of the disease has not been explicitly detected.
Class: Biologicals / Dog
Canglob DHLaPPi is
indicated for passive immunisation (treatment and prophylaxis)
are used to provide passive immunity in animals, for which active immunization
is not suitable, mostly in weakened animals, before transfers and exposed to
various other stress factors.
Dosage and administration:
0.4 ml / kg body weight (irrespective
of breed, age and sex).
Canglob DHLaPPi suspension / distemper virus
antibodies should be administered intravenously / intramuscularly or
Therapeutic dosage should
be administered daily until improvement of the health status (it may be used in
The preventive / prophylactic dose is 0.4
ml / kg of body weight given at 5-day intervals (it may be used in cases of an
immediate endangerment by a disease).
The highest daily dose is 0.4
ml / kg of body weight, which may be used both for therapy and prophylaxis.
The length of therapy of the prophylactic
protection and the route of administration should be assessed by a
Onset and Duration of immunity:
Dose 0.4 ml / kg of body weight stimulates
passive immunity for a period of approximately 5 days.
Passive immunity develops in dependence on a route
of administration. Its duration is dependent on an amount of the product
administered as well as on frequency of replications of the administration. On
intravenous administration, an immediate onset of the passive immunity is
recorded. But utilization of immunoglobulins is the highest. After
intramuscular and subcutaneous administration, a slightly delayed onset of the
passive immunity is recorded as well as immunity being lower as compared with
the i.v. administration.
/ Side effects / Contraindications /Warnings:
Do not use for prophylactic use in sensitized
animals or on an onset of allergic and anaphylactic reactions in cases of
immunization against infectious agents contained in the product is recommended
7 days after the last administration.
Pharmaceutical precautions / Instructions:
Store between 2 °C and
8 °C. Do not freeze. For animal treatment only.
Veterinary medicinal product to be supplied only on veterinary prescription.
Safety: Age / Pregnancy/ Withdrawal:
Age related safety and use in
pregnant and lactating bitches have not been stated by the manufacturer. IgY do not activate mammalian complement
system and do not bind to rheumatoid factor.
Substitute: Updating Soon
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